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Concomitant use or discontinuation of CYP450 isoenzymes which include CYP450 3A4 inducers, CYP450 3A4 inhibitors, or CYP450 2D6 inhibitors are complicated; concomitant use requires thorough thing to consider of the consequences on the parent drug, tramadol, as well as active metabolite, M1.L Lee – Jul 31, 2021 Could not imagine when the get i pos

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